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The FDA's Zepbound prescribing information specifically warns about acute kidney injury secondary to dehydration from prolonged GI side effects most cases are uncomfortable but not dangerous, but a small percentage need urgent medical care, and knowing the difference matters more than any single management tip

Relying on off-label use is an unreliable strategy for long-term treatment

A mean increase in heart rate has been observed with Trulicity, and sinus tachycardia is reported as an uncommon side effect

Adverse Reactions/Side Effects Generalized: Anaphylactic shock and death have been reported with administration of parenteral vitamin B 12 (see WARNINGS)

While the medication remains effective, injecting cold Ozempic may cause more discomfort or a stinging sensation